https://popups.uliege.be/3041-539x/index.php?id=2642 Publications of Auteurs Joris Van Poucke fr 0 https://popups.uliege.be/3041-539x/index.php?id=4595 The relational modeling strategy Robert Rosen introduced in chapter 5 of Life Itself in order to model biological organization is in many ways very remarkable, not in the least because he is able to give an account of final causation. This article gives an overview of the most characteristic steps of the relational modeling strategy, from the component to augmented abstract block diagrams, putting the emphasis on some epistemological aspects. Robert Rosen's modeling strategy is a formal representation of biological organization, specifically of circular causality. In this regard, the most important contribution of Robert Rosen is the anschaulichkeit - the intuitability - of the closure of the organization and of the intertwinement of the different Aristotelian causes, even if they are incommensurable. Mon, 14 Oct 2024 15:00:24 +0200 Mon, 14 Oct 2024 15:05:56 +0200 https://popups.uliege.be/3041-539x/index.php?id=4595 https://popups.uliege.be/3041-539x/index.php?id=2639 Systems Biology aims to take up the challenge of the post-genome era by developing means to handle the data flood in the contemporary 'omic' sciences. One of the challenges is to 'turn data into knowledge', which gives rise to the question of the functional meaning of the structural data. Systems Biology tries to answer this question by capturing the organisation of a biological system through mathematical and computational modelling. In this regard, however, there is some ambiguity concerning the notions of function, wholeness and system. In this paper, we intend to discuss this ambiguity by analysing the status of modelling in Systems Biology. We do so by articulating the source of the tensions between a relational and a mechanistic approach of living systems, and will inquire upon the potential relevance of a relational account for current Systems Biology. We draw upon Robert Rosen's relational account, in which functionality is an intrinsic and essential part of the organisation of a living system. An organism is complex, e.g. not amenable to a mechanistic, classical or engineering analysis. In this viewpoint, which is quite similar to Kant's, functionality has to be presupposed in order to 'save' the organism as a living system, It is the status of this presupposition that qualitatively distinguishes a mechanistic from a relational account, and it is the potentiality of that idea which deserves further investigation in current Systems Biology. Thu, 29 Aug 2024 15:33:42 +0200 Tue, 08 Oct 2024 13:05:18 +0200 https://popups.uliege.be/3041-539x/index.php?id=2639