AgNORs and PCNA immunoreactivity in early and advanced gastric carcinoma
Italo Bearzi,
Institute of Pathology, University of Ancona, Ospedale Nuovo Regionale, 60020, Torrette di Ancona, Italy
Renzo Ranaldi,
Institute of Pathology, University of Ancona, Ospedale Nuovo Regionale, 60020, Torrette di Ancona, Italy
Banafsheh Rezai,
Institute of Pathology, University of Ancona, Ospedale Nuovo Regionale, 60020, Torrette di Ancona, Italy
Corrado Sassaroli,
Institute of Pathology, University of Ancona, Ospedale Nuovo Regionale, 60020, Torrette di Ancona, Italy
Bruno Mannello,
Institute of Pathology, University of Ancona, Ospedale Nuovo Regionale, 60020, Torrette di Ancona, Italy
Abstract
In order to point out differences in the biological behaviour between early and advanced gastric carcinoma, their proliferative activity is evaluated on paraffin sections by silver staining of NOR particles and by immunohistochemical detection of PCNA. AgNOR particles were measured by a Leitz-Texture Analyzing System. The following variables were considered: nuclear area; area, number and percentage area of AgNOR; mean area of each AgNOR particle. The percentage of PCNA-positive nuclei was calculated. The results failed to show any significant difference of EGC compared to AGC. The possibility that differences in biological behaviour, other than the proliferative activity, could exist between EGC and AGC, is discussed.
Keywords : AgNOR, early gastric cancer, PCNA, proliferative activity
Pour citer cet article
Italo Bearzi, Renzo Ranaldi, Banafsheh Rezai, Corrado Sassaroli & Bruno Mannello, «AgNORs and PCNA immunoreactivity in early and advanced gastric carcinoma», Acta Stereologica [En ligne], Volume 11 (1992), Number 1 - Quantitative histopathology - Aug. 1992, 119-124 URL : https://popups.uliege.be/0351-580x/index.php?id=1870.