Long-term effect of ionizing irradiation on rat parafollicular cells at various activation levels of thyroid follicular cells
Metka Logonder-Mlinšek,
Institute of Histology and Embryology, Medical Faculty, University "E.Kardelj", Zaloška 4/I, P.O.Box 10, 61105 Ljubljana, Yugoslavia
Miroslav Kališnik,
Institute of Histology and Embryology, Medical Faculty, University "E.Kardelj", Zaloška 4/I, P.O.Box 10, 61105 Ljubljana, Yugoslavia
Matjaž Zwitter,
Institute of Oncology, Vrazov trg 4, 61105 Ljubljana
Majda Sušec-Michieli,
Institute of Biomedical Informatics, Medical Faculty, University "E.Kardelj", Vrazov trg 2, 61105 Ljubljana
Abstract
The aim of this experiment was to study the effect of local thyroid gland irradiation in rats, treated in preirradiation period either with thyroxine subcutaneously (s.c.), water s.c. or perchlorate perorally (p.o.). In 3 months postirradiation period all the animals received perchlorate p.o. The parafollicular cells have been analysed under the light microscope qualitatively and stereologically.
The perchlorate in the postirradiation period provoked a significant decrease in the total volume, total number and average cell volume. The effect of the irradiation with 12 Gy was negligible, but strong and significant with 18 Gy. This was expressed in the thyroxine and control group, though only slightly indicated in the group drinking perchlorate in preirradiation period.
The possible mechanism of protective action of the perchlorate on the parafollicular cells is discussed.
Keywords : ionizing irradiation, parafollicular cells, rat, sodium perchlorate, thyroid gland, thyroxine
Pour citer cet article
Metka Logonder-Mlinšek, Miroslav Kališnik, Matjaž Zwitter & Majda Sušec-Michieli, «Long-term effect of ionizing irradiation on rat parafollicular cells at various activation levels of thyroid follicular cells», Acta Stereologica [En ligne], Volume 4 (1985), Number 2 - Proceedings of the fourth European symposium for stereology - Dec. 1985, 133-138 URL : https://popups.uliege.be/0351-580x/index.php?id=3091.
