Stereological analysis of pathological changes in the blood-vessel wall after experimental induction of hypercholesterolemia
Vladimír Semecký,
Charles University, Pharmaceutic Faculty, Dept. of Biological and Medical Sciences, Heyrovského 1203, 50005 Hradec Králové, Czech Republic
Andrea Gojová,
Charles University, Pharmaceutic Faculty, Dept. of Biological and Medical Sciences, Heyrovského 1203, 50005 Hradec Králové, Czech Republic
Petr Nachtigal,
Charles University, Pharmaceutic Faculty, Dept. of Biological and Medical Sciences, Heyrovského 1203, 50005 Hradec Králové, Czech Republic
Kamila Langrová,
Czech Technical University, Faculty of Mechanical Engineering, Department of Mathematics, Karlovo nám. 13, 121 35 Praha'2, Czech Republic
Viktor Beneš,
Czech Technical University, Faculty of Mechanical Engineering, Department of Mathematics, Karlovo nám. 13, 121 35 Praha'2, Czech Republic
Abstract
The microarchitecture of blood-vessels of elastic type (aorta abdominalis, arteria iliaca) was observed at rabbits after a long time diet enriched by cholesterol. Using optical microscopy pathological changes along the blood-vessel were studied. Using the Cavalieri principle the volume of atherosclerotic lesions is estimated and the precision of estimators investigated. The permeability of blood-vessels is quantified by the ratio of lumen section area without and with plaques from transverse histological sections.
Keywords : atherosclerotic plaques, blood vessel wall, Cavalieri principle, stereological methods
Pour citer cet article
Vladimír Semecký, Andrea Gojová, Petr Nachtigal, Kamila Langrová & Viktor Beneš, «Stereological analysis of pathological changes in the blood-vessel wall after experimental induction of hypercholesterolemia», Acta Stereologica [En ligne], Volume 17 (1998), Number 3 - Dec. 1998, 383-388 URL : https://popups.uliege.be/0351-580x/index.php?id=364.