Quantitative morphological studies of the lung following inhalation of bacterial endotoxin
Robert Clark Lantz,
Departments of Anatomy and Microbiology, West Virginia University School of Medicine, Morgantown, WV 26506, USA
Robert Burrell,
Departments of Anatomy and Microbiology, West Virginia University School of Medicine, Morgantown, WV 26506, USA
Karen Birch,
Departments of Anatomy and Microbiology, West Virginia University School of Medicine, Morgantown, WV 26506, USA
David E. Hinton,
Departments of Anatomy and Microbiology, West Virginia University School of Medicine, Morgantown, WV 26506, USA
Abstract
To define the possible protective effect(s) of prior i.p. injection (tolerization) of an endotoxin preparation (LPS) against inhaled LPS, morphometric analysis of Syrian golden hamster lung was undertaken. Vv of PMNs and platelets in lung septal capillary blood was significantly increased in the nontolerized but LPS aerosol-exposed animals vs nontolerized control and tolerized, LPS aerosolized animals. While tolerization protected against cellular influx, lungs from tolerized, LPS aerosolized animals showed increased mean thickness of air-blood barrier. Although tolerization protected the animal from some effects of LPS inhalation, the process itself was associated with alteration in lung septum.
Pour citer cet article
Robert Clark Lantz, Robert Burrell, Karen Birch & David E. Hinton, «Quantitative morphological studies of the lung following inhalation of bacterial endotoxin», Acta Stereologica [En ligne], Volume 3 (1984), Number 1 - May 1984, 75-78 URL : https://popups.uliege.be/0351-580x/index.php?id=3959.