- Startpagina tijdschrift
- Volume 12 (1993)
- Number 1 - Sep. 1993
- The influence of experimental hyperthyroidism and hypothyroidism on mouse bone tissue
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The influence of experimental hyperthyroidism and hypothyroidism on mouse bone tissue
Abstract
The effect of L-thyroxine and sodium perchlorate on bone tissue in a 64-day long experiment was studied on 12 male mice. It was found that L-thyroxine caused a significant increase in the numerical areal density of osteoclasts and in the volume density of bone marrow cavities, while the volume density of mineralised bone was significantly decreased. The application of perchlorate caused a significant decrease in the numerical areal density of osteoclasts, in the volume density of bone marrow cavities and osteoid; the volume density of mineralised bone tissue was significantly increased in this condition.