Morphometry of the small intramyocardial arteries in long term diabetic rats

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• AS_4_n1_47_TAS (2,4M)

Abstract

The small intramyocardial arteries were investigated in 25 streptozotocin-induced diabetic rats at 11 to 40 weeks of diabetic state. The morphometric analysis was made using an eye-piece micrometer on a definite microscopic area. The mean arterial diameter and the mean arterial wall thickness ± standard deviation were determined in diabetic rats at 11, 19, 26, 33 and 40 weeks and compared with nondiabetic rats of the same age. The difference was statistically significant for the arterial wall thickness in animals with diabetes longer than 19 weeks: 8.84 ± 1.34 μm in diabetic rats at 19 weeks after the streptozotocin injection, versus 7.09 ± 0.69 μm in control group, 10.87 ± 0.89 μm in diabetic rats at 26 weeks versus 8.53 ± 0.66 μm in controls, 12.55 ± 1.03 μm in diabetic rats at 33 weeks versus 8.66 ± 0.22 μm in controls and 12.75 ± 0.66 μm in diabetic rats at 40 weeks versus 8.71 ± 0.52 μm in controls. In nondiabetic animals the arterial wall thickness increased with the normal ageing, but in a lower proportion. Our results are an experimental argument to the fact that the thickening of the small arteries could play a role in the diabetic cardiac damage.

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A propos de : Constantin Taşcă

A propos de : Cătălin Vasilescu

A propos de : Lucia Ştefăneanu