Morphological markers in cytology

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• AS_4_n2_245_BUR (1,1M)

Abstract

Morphological markers in cytology concern cytometric features of diagnostic relevance. These may be global size or shape descriptors, global photometric features, such as mean or total extinction of cellular constituents, and finally features describing the fine structure of the chromatin distribution in the nuclei. The role of cellular morphological markers and their validity with respect to different cytological tasks, such as diagnosis of cervical intraepithelial lesions, tumor diagnosis or typing and prognostic grading of cancer was investigated in gynecological smears and fine needle aspirates of the thyroid and the breast.

In all cases it was evident that chromatin pattern features, which can only reasonably be derived by local resolutions at the physical limits of light microscopy, are more powerful than global karyometric or photometric features.

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