- Startpagina tijdschrift
- Volume 3 (1984)
- Number 1 - May 1984
- Grading of postcapillary venules in lymph nodes: observer variation and reproducibility in subjective estimation and morphometric measurements
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Grading of postcapillary venules in lymph nodes: observer variation and reproducibility in subjective estimation and morphometric measurements
Abstract
We wanted to estimate variation and reproducibility in grading and in morphometric measurements of postcapillary venules. Five pathologists measured 100 postcapillary venules from 20 axillary lymph nodes by subjective and morphometric means. Range of variation was similar in subjective and morphometric measurements. The correlation coefficients between subjective and morphometric measurements varied from 0.62 to 0.93. On subjective grading of the individual postcapillary venules the kappa coefficient was 0.50 (90% limits: 0.40-0.56). On morphometry ICC was 0.74 (0.70-0.78). On morphometric measurements of individual lymph nodes ICC was 0.82. The results show that grading and morphometric measurements are very similar in respect to variability and reproducibility in this kind of experiment.