- Accueil
- Volume 3 (1984)
- Number 1 - May 1984
- Quantitative morphological studies of the lung following inhalation of bacterial endotoxin
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Quantitative morphological studies of the lung following inhalation of bacterial endotoxin
Abstract
To define the possible protective effect(s) of prior i.p. injection (tolerization) of an endotoxin preparation (LPS) against inhaled LPS, morphometric analysis of Syrian golden hamster lung was undertaken. Vv of PMNs and platelets in lung septal capillary blood was significantly increased in the nontolerized but LPS aerosol-exposed animals vs nontolerized control and tolerized, LPS aerosolized animals. While tolerization protected against cellular influx, lungs from tolerized, LPS aerosolized animals showed increased mean thickness of air-blood barrier. Although tolerization protected the animal from some effects of LPS inhalation, the process itself was associated with alteration in lung septum.