C. M. Wischik & A. W. Rogers

Array geometry of stromal progesterone response

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Abstract

The stereological parameters Vv (volume fraction), L3 (mean feature intercept), and λ (mean inter-feature free path) were used to describe the array geometry of stromal responses to progesterone in the rat uterus. Stromal cells in the ovariectomized rat form a topologically continuous matrix, having a uniform internal geometry. The response to progesterone is non-uniform across the array. In the stroma immediately underlying the luminal epithelium, the cell enlargement, which is significant at 3 hours, is not associated with extracellular changes. In deep stroma near muscularis, cell enlargement is delayed until 7 hours, and is then accompanied by a considerable expansion in the extracellular space. The non-uniformity of these responses suggests that cell activities are constrained by local factors to do with the geometry of the array, which may originate from other cell classes, or may be intrinsic to the array.

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Over : C. M. Wischik

Over : A. W. Rogers