Acta Stereologica

0351-580X

 

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Anita H.M. Naukkarinen & Kari J. Syrjänen

Effects of local and systemic administration of anti macrophage serum on post capillary venules in the bursal T cell area of SRBC-immunized chickens

(Volume 2 (1983) — Number 2 - Proceedings of the second symposium on morphometry in morphological diagnoses, september 7-9, 1983, Kuopio, Finland - Dec. 1983)
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Abstract

The effects of rabbit anti chicken macrophage serum (RACMS) on the morphology of the diffusely infiltrated area (DIA; the bursal T cell region) of chickens stimulated locally (per anum) with SRBC (a T cell dependent antigen) were studied morphometrically.

Local administration of RACMS caused pronounced morphological alterations in the post capillary venules (PCVs) of the DIA in SRBC-immunized chickens; significant decrease (p<0.001) in the diameter of the PCV (Dpcv) and its lumen (Dlu) due to the flattening of the endothelial cells. The decrease in the migration index was significant (p<0.001) as well. Local administration of RACMS decreased the percentage of MPS cells to some degree (p<0.02), whereas systemic administration of RACMS caused a highly significant decline (p<0.001) in the percentage of these cells.

This study confirms the important function of MPS cells in a T-dependent immune response, and further suggests that also circulating MPS cells like T and B lymphocytes may use the PCVs as route of migration from blood to lymphatic tissue.

Om dit artikel te citeren:

Anita H.M. Naukkarinen & Kari J. Syrjänen, «Effects of local and systemic administration of anti macrophage serum on post capillary venules in the bursal T cell area of SRBC-immunized chickens», Acta Stereologica [En ligne], Volume 2 (1983), Number 2 - Proceedings of the second symposium on morphometry in morphological diagnoses, september 7-9, 1983, Kuopio, Finland - Dec. 1983, 431-437 URL : https://popups.uliege.be/0351-580x/index.php?id=4284.

Over : Anita H.M. Naukkarinen

Department of Pathology, University of Kuopio, P.O.Box 6, SF 70211 Kuopio, Finland

Over : Kari J. Syrjänen

Department of Pathology, University of Kuopio, P.O.Box 6, SF 70211 Kuopio, Finland