Quantitative characterisation of ageing hepatocytes

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• AS_2_n2_408_DAV (1.1M)

Abstract

Hepatocytes of rats of various ages were investigated morphometrically and qualitatively.

During the postnatal development and ageing

- the volume of hepatocytes increases from 5800 µm³ to about 10000 µm³ in 6 months and then decreases to 7300 µm³ (24th-27th months).

- the number of hepatocytes increases from 41.4 x 10⁶ at birth to 1150 x 10⁶ (6th month).

- the volume of hepatocyte nuclei increases from 410 µm³ at birth to 840 µm³ at the 12th month and decreases thereafter to 470 µm³ at the 27th month.

- the volume density of mitochondria decreases from 0.165 at birth to 0.128 at the 27th month.

- the number of mitochondria increases from 200 at birth to 2200 in the 6th month and decreases thereafter to 1520 at the 27th month.

- the volume of the average mitochondrion decreases from 3.83 µm³ (at birth) to 0.53 µm³ (27th month).

- the surface of the hepatocytes increases from 1900 µm² to 2780 µm².

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About: Heinz David