Morphometry of connective tissue in rat livers

Otto Löw; Ulrich Gabler; Andreas Müller; Petra Gabler; Harald Schubert; Hans-Christoph Löw; Georg Machnik

Acta Stereologica

0351-580X

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Otto Löw, Ulrich Gabler, Andreas Müller, Petra Gabler, Harald Schubert, Hans-Christoph Löw & Georg Machnik

Morphometry of connective tissue in rat livers

(Volume 13 (1994) — Number 1 - Proceedings of the sixth European congress for stereology - Part two - May 1994)

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AS_13_n1_101_LOW (2.0M)

Abstract

Thioacetamide (TAA) induced fibrosis in the rat liver was used as a model for testing preparations for a prevention of cirrhosis. The homogeneity of collagen distribution between the lobes allows the morphometry of a single lobe as a measure for the total organ, but it is always better to estimate about 5 stage sections with equal distances, and these sections should be measured totally.

A test period of 3 months results in a markable fibrosis, sufficient for testing antifibrotic preparations.

Zinc ions in drinking water decrease the collagen percentages in comparison to untreated animals and reduce the TAA-induced fibrosis during simultaneously application over a 3 month period, since an addition only in the 3rd month diminishes this effect. No differences are seen after an interruption of the TAA-poisoning after 3 months and a feeding with zinc sulphate only in the 4th month, compared to clear drinking water.

Keywords : connective tissue, methodology, rat liver, thioacetamide, zinc sulphate

To cite this article

Otto Löw, Ulrich Gabler, Andreas Müller, Petra Gabler, Harald Schubert, Hans-Christoph Löw & Georg Machnik, «Morphometry of connective tissue in rat livers», Acta Stereologica [En ligne], Volume 13 (1994), Number 1 - Proceedings of the sixth European congress for stereology - Part two - May 1994, 101-106 URL : https://popups.uliege.be/0351-580x/index.php?id=4533.