Volume-weighted mean nuclear volume in dysplastic glands from the ventral prostate of rats treated with cadmium chloride, and resembling human prostatic intraepithelial neoplasia

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Abstract

Estimates of volume-weighted mean nuclear volume have been perfoimed in dysplastic epithelium from ventral prostate of rats treated with chronic oral exposure to cadmium chloride. The nuclear size of dysplastic cells was significantly increased in compaiison to both controls and treated non-dysplastic acini. The high variability detected in the lowest level of sampling for the measurements of dysplastic glands may be due to the important hetereogeneity of their nuclei, similar to that observed in human prostatic intraepithelial neoplasia. The estimation of nuclear V_v, could prove interesting to study the behaviour of both neoplastic and pre-neoplastic lesions in experimental carcinogenesis as it has been stated for human tumors.

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